Detalhe da pesquisa
1.
Directed Biosynthesis of Mitragynine Stereoisomers.
J Am Chem Soc
; 145(9): 4957-4963, 2023 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36883326
2.
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
J Pharmacol Exp Ther
; 385(3): 180-192, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37019472
3.
Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.
J Nat Prod
; 86(4): 1042-1052, 2023 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36913648
4.
Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics.
Int J Mol Sci
; 24(21)2023 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37958703
5.
Interactive Effects of µ-Opioid and Adrenergic-α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine.
J Pharmacol Exp Ther
; 383(3): 182-198, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36153006
6.
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
Drug Metab Dispos
; 50(2): 158-167, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34759012
7.
Characterization of Different Forms of Kava (Piper methysticum) Products by UPLC-MS/MS.
Planta Med
; 88(14): 1348-1359, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34839465
8.
Kratom use as more than a "self-treatment".
Am J Drug Alcohol Abuse
; 48(6): 684-694, 2022 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35767669
9.
Need for clarity and context in case reports on kratom use, assessment, and intervention.
Subst Abus
; 43(1): 1221-1224, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35657649
10.
Acute Renal Insufficiency Associated With Consumption of Hydrocodone- and Morphine-Adulterated Kratom (Mitragyna Speciosa).
J Emerg Med
; 63(1): e28-e30, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35940982
11.
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain.
Molecules
; 27(11)2022 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684553
12.
Acute morphine blocks spinal respiratory motor plasticity via long-latency mechanisms that require toll-like receptor 4 signalling.
J Physiol
; 599(15): 3771-3797, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142718
13.
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for µ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
J Pharmacol Exp Ther
; 376(3): 410-427, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33384303
14.
Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats.
J Nat Prod
; 84(4): 1104-1112, 2021 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620222
15.
Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors.
J Nat Prod
; 84(4): 1034-1043, 2021 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33635670
16.
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.
Planta Med
; 86(17): 1278-1285, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32693425
17.
Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands.
Med Chem Res
; 29(9): 1697-1706, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-33584084
18.
Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives.
J Pharmacol Exp Ther
; 368(2): 272-281, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530624
19.
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom).
Xenobiotica
; 49(11): 1279-1288, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30547698
20.
Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
Addict Biol
; 24(5): 874-885, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29949228